Antagonists Selective for Estrogen Receptor α
نویسندگان
چکیده
منابع مشابه
Antagonists Selective for Estrogen Receptor α.
To develop compounds that are antagonists on ER , but not ER , we have added basic side-chains typically found in nonsteroidal antiestrogens to pyrazole compounds that bind with much higher affinity to ER than to ER . In this way we have developed basic side-chain pyrazoles (BSC-pyrazoles) that are high affinity, potent, selective antagonists on ER . These BSCpyrazoles are themselves inactive o...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2002
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.143.3.8704